Geneva: The World Health Organization (WHO) guideline development group on Friday (January 14, 2022) approved two arthritis drugs called baricitinib and interleukin-6 (IL-6) in combination with corticosteroids to treat patients with severe or severe COVID-19. recommended use of. ,
“Today’s recommendations are based on new evidence from seven trials involving more than 4,000 patients with non-severe, severe and severe COVID-19 infections,” the group said in the British Medical Journal.
Trials have shown that combining corticosteroids with baricitinib and IL-6 — drugs from the Janus kinase inhibitor (JAK) group used to treat rheumatoid arthritis — improves survival rates and has no adverse effects. Reduces the need for pulmonary ventilation.
Experts said, “When both are available, they suggest choosing either one based on cost, availability and experience of the physician. Using both the drugs at the same time is not recommended.”
In addition, experts advised against the use of two other JAK inhibitors, known as ruxolitinib and tofacitinib. COVID-19 patients In severe or critical condition, as limited trials have shown no benefit with the potential occurrence of serious side effects.
The WHO guideline update also recommends the use of monoclonal antibody drugs, such as sotrovimab and casirivimab/imdevimab, in mild patients. COVID-19, but only in those at highest risk of hospitalization. Experts noted that there is not enough evidence to recommend one type of monoclonal antibody treatment over another.
The updated guideline complements WHO’s previous recommendations on the use of IL-6 receptor blockers and systemic corticosteroids in patients with severe or severe COVID-19; Conditional recommendations on the use of casirivimab/imdevimab (another monoclonal antibody treatment) in select patients; and against the use of convalescent plasma, ivermectin and hydroxychloroquine in patients regardless of disease severity.
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