Researchers from the University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health describe how a pair of fundamental genetic and cellular processes are exploited by cancer cells to promote tumor survival and growth. Is. The findings appear in the journal European Organization for Molecular Biology. Cancer is driven by a variety of genetic alterations, ranging from small insertions and deletions in DNA mutations and copy number alterations to whole-genome duplication events. Collectively, somatic copy number alterations in tumors often result in an abnormal number of chromosomes, termed aneuploidy, which have been shown to promote tumor growth by increasing genetic diversity, instability, and growth.
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