Queensland: A new research led by researchers from the University of Queensland has demonstrated a link between endometriosis and ovarian cancer subtypes, helping them to identify potential drug targets for therapy and to increase understanding of both diseases.
The study was published in the journal ‘Cell Reports Medicine’. Previous studies have shown that endometriosis sufferers have a slightly higher risk of developing epithelial ovarian cancer.
Dr. Sally Mortlock and Professor Grant Montgomery from UQ’s Institute for Molecular Bioscience conducted a large genetic study to identify the genetic basis of this risk in order to better understand the biological overlap between these reproductive disorders.
“More information is needed about how they develop, their associated risk factors, and the pathways shared between endometriosis and different types of ovarian cancer,” Mortlock said.
Endometriosis is a chronic debilitating disease that affects the health of 1 in 9 women of reproductive age, where tissue similar to the lining of the uterus grows in other parts of the body, causing pain and infertility.
“Our research suggests that individuals with certain genetic markers predisposed to endometriosis have a higher risk of certain epithelial ovarian cancer subtypes, namely clear cell and endometriosis ovarian cancer,” Mortlock said.
She also noted that although the diseases are genetically linked, the risk of ovarian cancer is not substantially increased for people with endometriosis.
“Overall, studies have estimated that 1 in 76 women are at risk of developing ovarian cancer in their lifetime and that having endometriosis increases this to 1 in 55, so the overall risk is still very low. ,” He said.
The study found genes that could be drug targets in the future for treating both endometriosis and epithelial ovarian cancer. “We discovered specific regions of DNA that increase the risk of both diseases and identified genes in ovary and uterine tissue that could be targeted for therapy and to understand the link between disorders and cancer-initiating biologicals.” Could be valuable for disrupting pathways,” Dr. Mortlock added.
The researchers combined the large dataset to find overlap in risk factors between the two diseases, comparing the genomes of 15,000 people with endometriosis and 25,000 with ovarian cancer.
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