Singapore: the overall risk of myopericarditis – A condition that causes inflammation in the heart muscle – according to a study published in The Covid-19 vaccination is very low, affecting 18 people per million vaccine doses. Lancet Respiratory Medicine Journal,
Research confirms that the risk of myopericarditis is comparable or lower after covid-19 vaccination than with other non-Covid-19 vaccines.
The team analyzed international databases, looking at more than 400 million vaccination doses, to compare the risk of myopericarditis following vaccination against Covid-19 and other diseases such as influenza and smallpox.
They found no statistically significant difference between the incidence of myopericarditis after Covid-19 vaccination – 18 cases per million doses – and other vaccinations, which was 56 cases per million doses.
“Our research shows that the overall risk of myopericarditis is no different for this newly approved group of vaccines against Covid-19, compared to vaccines against other diseases,” he said. kollengode ramanathanfrom National University HospitalSingapore and the corresponding author of the study.
“The risk of such rare events must be balanced against the risk of myopericarditis from infection, and these findings should strengthen public confidence in the safety of COVID-19 vaccination,” Ramanathan said.
Myopericarditis can, in some cases, cause severe permanent heart damage. It is most often caused by a virus but in rare cases can also occur after vaccination.
There have been reports of myopericarditis following mRNA-based COVID-19 vaccination, particularly in adolescents and young adults.
The researchers analyzed more than 20 studies with a reported incidence of myopericarditis after any type of vaccination between January 1947 and December 2021.
The researchers said that among Covid-19 vaccinations, the risk of myopericarditis was higher for those receiving mRNA vaccines (22.6 cases per million doses) compared to non-mRNA vaccines (7.9 cases per million doses).
Reported cases are higher in people under 30 (40.9 cases per million doses), men (23 cases per million doses), and even more after the second dose of the COVID-19 vaccine (31.1 cases per million doses). were.
“The occurrence of myopericarditis following non-Covid-19 vaccination may suggest that myopericarditis is a side effect of any vaccination-induced inflammatory processes and is not unique to the SARS-CoV-2 spike protein in COVID-19 vaccines or infections. ,” said Jyoti Somanifrom the National University Hospital, Singapore, and a co-author of the study.
Somani said, “It also highlights that the risk of such adverse adverse events should be offset by the benefits of vaccination, including a lower risk of infection, hospitalization, serious illness and risk of contracting COVID-19.” Death is involved.”
The researchers acknowledge some limitations with their study.
They noted that their findings include only a small proportion of children under the age of 12 who are recently eligible for vaccination, and that the results of this study cannot be generalized to this age group.
Research confirms that the risk of myopericarditis is comparable or lower after covid-19 vaccination than with other non-Covid-19 vaccines.
The team analyzed international databases, looking at more than 400 million vaccination doses, to compare the risk of myopericarditis following vaccination against Covid-19 and other diseases such as influenza and smallpox.
They found no statistically significant difference between the incidence of myopericarditis after Covid-19 vaccination – 18 cases per million doses – and other vaccinations, which was 56 cases per million doses.
“Our research shows that the overall risk of myopericarditis is no different for this newly approved group of vaccines against Covid-19, compared to vaccines against other diseases,” he said. kollengode ramanathanfrom National University HospitalSingapore and the corresponding author of the study.
“The risk of such rare events must be balanced against the risk of myopericarditis from infection, and these findings should strengthen public confidence in the safety of COVID-19 vaccination,” Ramanathan said.
Myopericarditis can, in some cases, cause severe permanent heart damage. It is most often caused by a virus but in rare cases can also occur after vaccination.
There have been reports of myopericarditis following mRNA-based COVID-19 vaccination, particularly in adolescents and young adults.
The researchers analyzed more than 20 studies with a reported incidence of myopericarditis after any type of vaccination between January 1947 and December 2021.
The researchers said that among Covid-19 vaccinations, the risk of myopericarditis was higher for those receiving mRNA vaccines (22.6 cases per million doses) compared to non-mRNA vaccines (7.9 cases per million doses).
Reported cases are higher in people under 30 (40.9 cases per million doses), men (23 cases per million doses), and even more after the second dose of the COVID-19 vaccine (31.1 cases per million doses). were.
“The occurrence of myopericarditis following non-Covid-19 vaccination may suggest that myopericarditis is a side effect of any vaccination-induced inflammatory processes and is not unique to the SARS-CoV-2 spike protein in COVID-19 vaccines or infections. ,” said Jyoti Somanifrom the National University Hospital, Singapore, and a co-author of the study.
Somani said, “It also highlights that the risk of such adverse adverse events should be offset by the benefits of vaccination, including a lower risk of infection, hospitalization, serious illness and risk of contracting COVID-19.” Death is involved.”
The researchers acknowledge some limitations with their study.
They noted that their findings include only a small proportion of children under the age of 12 who are recently eligible for vaccination, and that the results of this study cannot be generalized to this age group.