Canterbury: In a recent study, researchers have identified a potential new treatment that suppresses the replication of SARS-CoV-2, the virus that causes COVID-19. In order to multiply, all viruses, including coronaviruses, infect cells and reprogram them to produce novel viruses. The study ‘Targeting the pentose phosphate pathway for SARS-CoV-2 therapy’ has been published by the scientific journal Metabolite.
Research has shown that cells SARS-CoV-2 . infected with Novel coronaviruses can arise only if their metabolic pentose phosphate pathway is active.
When applying the drug benafuxythiamine, an inhibitor of this pathway, SARS-CoV-2 replication was suppressed and infected cells did not produce coronaviruses.
Research from the University of Kent’s School of Biosciences and the Institute of Medical Virology, Goethe-University, Frankfurt am Main found that the drug also enhanced the antiviral activity of ‘2-deoxy-D-glucose’; A drug that modifies the metabolism of the host cell to reduce the multiplication of the virus.
This suggests that pentose phosphate pathway inhibitors such as benfuoxythiamine are a potential new treatment option for COVID-19, both on their own and in combination with other therapies.
Additionally, the antiviral mechanism of Benfoooxythiamin differs from Other COVID-19 medicines such as remdesivir and molanupiravir. Therefore, viruses resistant to these may be sensitive to benfuoxythiamine.
Professor Martin Michaelis from the University of Kent said, “This is a breakthrough in the research of COVID-19 treatments. Since resistance development is a major problem in the treatment of viral diseases, it is very important to have therapies that use different targets and so forth. It is expected to develop the most effective treatment for COVID-19.”
“Targeting virus-induced changes in host cell metabolism in particular is an attractive way to interfere with the virus replication process,” said Professor Jindrich Sintal from the Goethe-University Frankfurt.
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